Associate Scientist I, Fibrosis
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POST DATE 9/16/2016
END DATE 1/13/2017
Gilead Sciences, Inc
Foster City, CA
JOB DESCRIPTIONSPECIFIC RESPONSIBILITIES
Gilead seeks a highly talented and motivated laboratory scientist to support discovery and development of therapeutic agents to treat chronic fibrotic diseases including non-alcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF) and diabetic kidney disease. The successful candidate will participate in the discovery and translational research efforts aimed at identifying and characterizing novel therapeutic targets, investigating the mechanism of action of therapeutics, and defining optimal drug combinations. The successful candidate will work within an established group focused on fibrotic diseases and will be able to effectively interface with multidisciplinary project teams.
* Development and execution of cell-based assays using cell lines and primary human cell cultures to investigate mechanism of action of novel therapeutics.
* Assessing therapeutic potential of new drugs by analysis of various tissues (e.g. liver, lung, kidney, adipose) from pre-clinical rodent models.
* Identification of new technologies that may increase our understanding of disease mechanisms.
* Close collaboration with other members of fibrosis group and cross-functional project team.
ESSENTIAL DUTIES AND JOB FUNCTIONS
Independently plans and executes assigned experiments that support non-routine research activities and project goals.
Applies advanced level of understanding project goals and methods.
Selects appropriate methods and techniques in performing experiments.
Collaborates with supervisory personnel to develop research methods.
May lead functional group meetings. Presents results of work, interprets data, and draws conclusions regarding presented material and nature of work.
Acts as a resource for other employees within the department.
Maintains familiarity with scientific literature and applies appropriately to research projects.
Uses strong communication skills (both verbal and written) and interpersonal skills to communicate objectives and results.
Must think critically and creatively and be able to work independently, determine appropriate resources for resolution of problems and have strong organizational and planning skills.
KNOWLEDGE, EXPERIENCE AND SKILLS
9+ years of experience with BS degree in a related scientific discipline.
8+ years of experience with MS degree in a related scientific discipline.
Prior knowledge and research experience in diseases associated with tissue inflammation, fibrosis and/or metabolic disease is a plus. Necessary technical skills include western blotting, tissue homogenization, ELISA, qPCR/Nasnostring. Extensive cell culture experience including human primary cell cultures (hepatocytes, stellate cells, fibroblasts, macrophages) and/or development of various cell-based assays is required. Expertise in flow cytometry, use of small-molecule inhibitors and genomic data analysis is a plus. Proficiency with basic data analysis programs (Excel, GraphPad Prism, etc) and application of statistics is essential. Applicants must have excellent communication skills (both verbal and written), and strong organizational and planning skills. The successful candidate needs to be able to manage more than one project at any given time, and work in a fast-paced, cross-functional and highly collaborative team environment.
As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact email@example.com for assistance.
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