COMPUTATIONAL BIOINFORMATICIAN I / 40 HOURS / DAYS / BWH - PATH BIOINFORMATICS
GENERAL SUMMARY/OVERVIEW STATEMENT:
The Center for Advanced Molecular Diagnostics (CAMD) is the clinical molecular diagnostics laboratory for three Harvard Medical School hospitals: Brigham and Women's Hospital, Dana-Farber Cancer Institute, and for the pediatric cancer patients of Boston Children's Hospital. Our mission is to provide innovative molecular and cytogenetic diagnostic services to assist with the clinical care of patients in our hospitals and affiliated clinics, with a primary focus on cancer care. This is exemplified by the PROFILE program, which is a collaborative effort to advance translational and personalized cancer medicine by implementing tumor genomic profiling for all cancer patients who receive care at one of the collaborating hospitals. PROFILE employs state-of-the art genomics technology to generate a detailed report of medically actionable genetic alterations in a CLIA-certified and real-time process to facilitate rapid clinical application. These cancer genomic profiles are being used to guide patient treatment and/or stratification for clinical trials of novel anticancer agents.
Working under very general supervision, the Computational Bioinformatician I will have demonstrated competency is one of more of the following areas of specialization: algorithm development, data analysis, quality assurance/testing, pipeline software/computing development, user interface design & report development, web-based application development, Laboratory Information Management System (LIMS) development, or report development, as described below.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
Working in a progressive and academic medical center, the Bioinformatics Analyst will be responsible for the execution, debugging, and ongoing validation of our analysis pipelines. The successful candidate must be able to communicate effectively with both software developers and lab personnel. More specifically, the position will have the following responsibilities:
Responsible for ensuring the timely processing of all samples through our analysis pipelines
Serve as the primary point of contact for troubleshooting and debugging issues as they arise
Generation of QC reports and monitoring of pipeline metrics over time
Work with lab and bioinformatics team members to optimize and streamline operations
Assist in validating changes to the pipeline before they are released into production
Bachelor's degree in bioinformatics or related field and 2 years of experience or Masters degree
Database experience with MySQL
Must be proficient with Java or Python. Experience with R is a plus.
Prior experience analyzing Illumina sequencing data is required
Must be familiar with common NGS tools (GATK, Picard, samtools, etc)
Understanding of Cancer Biology is preferred
Excellent verbal and written communication skills
Prior experience testing software in a CLIA regulated environment is preferred
Fast paced laboratory environment with large workload and frequent deadlines
Brigham and Womens Hospital is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, sexual orientation, protected veteran status, or on the basis of disability.
Brigham and Womens Hospital I CARE Standards
The I CARE Standards guide me in my interactions with patients, family members, visitors, colleagues, and neighbors in my workplace and surrounding community to optimize the Brigham experience and help fulfill my role in our mission of providing seamless, high quality patient and family centered care.
C.I will Communicate my commitment to high quality performance
A.I will Appear and act as a professional
R.I will Respect all individuals
E.I will Extend myself