Clinical Research Coord. I
The Clinical/Tissue Core has been an important component of the Center for the Study of Inflammatory Bowel Disease since its inception, serving as the nexus between investigators exploring the etiology and pathophysiology of the inflammatory bowel diseases and patients with these conditions. The Clinical/Tissue Core has supported the needs of researchers both within and external to the CSIBD through a number of highly organized efforts designed to facilitate connections between bench top and clinic, specifically the IBD and control patient base within the MGH Crohns & Colitis Center and the gastroenterology practice at Massachusetts General Hospital. To date, these efforts have included: 1) an extensive clinical database of patients with inflammatory bowel disease seen at the Massachusetts General Hospital, with detailed phenotypic and environmental information, 2) biospecimen samples in the form of blood for genotypic analysis and next-generation sequencing, stool for microbiome analysis, urine for metabolomics and identification of novel inflammatory markers, 3) tissue sections from biopsies and resected specimens, 4) a serum bank, 5) immortalized lymphocytes from IBD probands, as well as their affected and unaffected first degree relatives, and 6) clinical research support for translational studies.
The incumbent will be responsible for working alongside CSIBD investigators and research staff to recruit subjects, collect and process biospecimens, and ensure all research is conducted in compliance with Partners Human Research Committee policies.
Protocol Development and Maintenance
Preparation and submission of Human Subjects Research protocols to Internal Review Board for new submissions, amendments, and continuing reviews
Maintenance/management of onsite regulatory binders
Telephone calls to enrolled participants to request return visits and/or to complete follow-up questionnaires
Coordinate long-distance correspondence with out-of-state families
Biospecimen sample collection:
Collection of biopsies during surgical resections and colonoscopies
Labeling and storage of biological specimens, including blood, stool, intestinal biopsies, and saliva using FreezerWorks and coding conventions
Aliquot samples, extract RNA and/or DNA, and track samples to/from collaborators
Ensure necessary Data Use Agreements and Materials Transfers Agreements in place prior to sharing of data and/or specimens
Coordinate sample collection from out-of-state participants (consent, pre-paid shipping)
QA/QC of previously entered data in StudyTRAX, as needed, to confirm accuracy and completeness
Ensure that all data is appropriately collected and managed
Query StudyTRAX for further analysis as requested by investigators and collaborators
Prepare results for presentation, publication and progress reports
Develop and/or follow protocols for data processing
Collaborate with the Clinical Study Team to create and edit case report forms (CRF)
Bachelors degree required, preferably in basic or life sciences
Computer skills (including MS Excel)
Strong command of English language, including medical and scientific terminology
The ability to work individually and as part of a team
Willing to travel to Newton-Wellesley Hospital, North Shore Medical Center, and/or The Broad Institute for meetings, subject recruitment and biospecimen transfer (transportation will be provided, drivers license required).
Exceptional organizational skills and the flexibility to handle multiple tasks and deadline pressures
Effective analytical skills
Excellent interpersonal/communication skills
Experience with REDCap, StudyTRAX, and/or FreezerWorks preferred but not required
Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.