Director, Modeling & Simulation (Pharmacometrician) at Vertex

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POST DATE 9/18/2016
END DATE 10/23/2016

Vertex Boston, MA

Boston, MA
AJE Ref #
Job Classification
Full Time
Job Type
Company Ref #
Entry Level (0 - 2 years)


Modeling & Simulation methodologies plays an increasingly important role in the development of new drugs within Vertex Pharmaceuticals and our goal is to fully implement Model based principles to support drug development program in terms of translational modeling, clinical trial design, dose selection and to improve critical decision making.

We are now seeking an experienced Pharmacometrician to our Modeling & Simulations (M&S) group to help us achieve this vision.

The successful candidate will be responsible for developing and executing M&S strategies in cross functional drug development project teams in close collaboration with colleagues in Clinical Pharmacology, Biostatistics, Research and other colleagues within the clinical and preclinical organization. The successful candidate will play a key role in building the Pharmacometrics and Modeling capability within Vertex by strongly contributing to the continuous improvement of our technical skill, computational infrastructure and the strategic use of M&S methodologies across our projects and disease areas.

Key responsibilities
As M&S lead in one or more cross functional drug development teams, develop and execute Modeling & Simulation plans fully integrated with the overall clinical plans

By using state of the art Modeling&Simulation methodologies strongly contribute to decision making at critical milestones based on quantitative principles in close collaboration with Biostats, Clin Pharm and other quantitative disciplines

Perform population PK, PKPD-analyses, Clinical trial simulations and other model based analyses on a regular basis

Initiate and coordinate outsourced Modeling & Simulation activities when appropriate

Provide technical and tactical support to other Modeling colleagues

Strengthen our internal Modeling & Simulation capability on a continuous basis by initiating training activities, evaluating and incorporating new M&S tools as appropriate