Director, Pharmacology

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POST DATE 9/3/2016
END DATE 11/13/2016

Five Prime Therapeutics, Inc. South San Francisco, CA

South San Francisco, CA
AJE Ref #
Job Classification
Full Time
Job Type
Company Ref #
Entry Level (0 - 2 years)
Doctoral Degree


div id="contentwrapper" p strong Five Prime Therapeutics, Inc.  /strong (NASDAQ: FPRX) is a clinical-stage biotechnology company focused on discovering and developing innovative immuno-oncology protein therapeutics to alter the tumor microenvironment to enhance tumor cell killing. Our company has a growing portfolio of product candidates and currently has three protein therapeutics in clinical development.  /p ul li style="text-align:justify" Cabiralizumab (FPA008) – a monoclonal antibody targeting CSF1R in a Phase 1/2 clinical trial in pigmented villonodular synovitis (PVNS) and in a Phase 1a/1b clinical trial in multiple cancers in combination with Bristol-Myers Squibb Company’s PD-1 immune checkpoint inhibitor, Opdivo® (nivolumab) /li li style="text-align:justify" FPA144 – a monoclonal antibody targeting FGFR2b in a Phase 1 clinical trial in FGFR2b over-expressing gastric cancer /li li style="text-align:justify" FP-1039 – an FGF ligand trap in a Phase 1b clinical trial in mesothelioma /li /ul p Five Prime has a differentiated target discovery platform and library that we use to rapidly interrogate the entire extracellular proteome in medically relevant  em in vitro  /em and  em in vivo /em  models to discover novel targets and drug leads.  Our technology has been validated by our growing pipeline and through multiple collaborations with pharmaceutical companies, including Bristol-Myers Squibb, UCB Pharma, S.A. and GlaxoSmithKline across a range of therapeutic areas.  FivePrime is committed to innovation and outstanding science, values that are reflected in our people and our products. Discover more about FivePrime at a href="/" /a . /p h2 The Position: /h2 p We are seeking a motivated and ambitious individual to join the Pharmacology team within the Development Science organization as a Director of Pharmacology.  This individual will lead pharmacology staff consisting of PhD level scientists and research associates that focuses on the em in vivo /em validation and development of FivePrime’s pipeline of preclinical and clinical therapeutics and antibodies.  The position reports to the Vice President of Pharmacology. /p h2 Responsibilities: /h2 ul li style="text-align:justify" Representing pharmacology functions on multiple immuno-oncology project teams and to senior management. /li li style="text-align:justify" Selection, management and oversight of mouse tumor models to support preclinical and clinical programs. /li li style="text-align:justify" Writing and authorizing study protocols and reports. /li li style="text-align:justify" Authorizing appropriate sections of regulatory documents (INDs, CTA, BLAs) /li li style="text-align:justify" Management of PhD and associate-level staff to execute department and corporate goals. /li /ul