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Principal Research Associate, Antibody Engineer

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POST DATE 9/11/2016
END DATE 11/20/2016

Moderna Therapeutics Cambridge, MA

Cambridge, MA
AJE Ref #
Job Classification
Full Time
Job Type
Company Ref #
Mid-Career (2 - 15 years)
Bachelors Degree


Principal Research Associate, Antibody Engineer


Moderna seeks a highly skilled and motivated Principal Research Associate, Antibody Engineer to be involved in the technical support of protein engineering and early discovery for novel applications of Moderna s mRNA technology platform. The position will support antibody/biologic protein discovery programs within New Venture Labs. The ideal candidate will have demonstrated capacity to function in a fast-paced environment on cross-functional teams, the level of the position will be commensurate with capabilities.


* Develop in vitro/ cell-based assays

* Responsible and accountable for the execution of well-controlled in vitro/ex vivo experiments and for communicating experimental findings in a timely fashion (Powerpoint)

* Assist in study designs and in vivo work on a per request basis

* Thrive in a collaborative environment and seek/provide help and support from/to other members of the Moderna team across venture/non venture boundaries

* Performance of in vitro binding assays ie: ELISA, FACS, luciferase, Western blotting, cell proliferation

* Protein-protein binding assays such as OCTET, Biacore or other methods to determine Ab affinity.

* Protein expression, purification and characterization.

* Mammalian cell culture.

* General laboratory assistance including lab equipment maintenance, preparation of reagents, and the ordering and receiving of lab supplies

* Closely collaborate with other members within the research group and broadly with departments throughout the company

* Record and communicate findings


* BS with 3 years of experience in biology, biochemistry, or other related discipline

* Hands on experience with mammalian cell culture (cell lines and primary cells) and transfection for protein production

* Hands on experience with cell-based assays

* Lab experience in small scale protein purification techniques, including affinity and SEC

* Lab experience with ELISA

* Excellent interpersonal and collaborative skills, and the ability to work independently and effectively in a highly dynamic environment


* Experience with FACS, cell culture

* Experience with either OCTET and/or Biacore

* Understanding of molecular biology techniques

* 3 years industrial experience Preferred Experience: 8 + years in a cGMP laboratory with focus in microbiology

* Preferred Knowledge: rapid microbiological methods, LIMS

* Preferred Skills: microbial identifications

* Expertise in industry standards and guidelines, including USP/EP compendia testing requirements

* A proven track record of supporting the implementation of environmental monitoring programs


* Multiple laboratory research techniques

* Operates independently

* Ability to carry multiple experimental avenues in parallel

* Ability to interact with program teams

* Strong communication skills (oral and written)

* Goal orientation

* Ability to adapt to change