Principal Scientist, In Vitro Toxicology

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POST DATE 8/10/2016
END DATE 1/18/2017

Celgene San Diego, CA

San Diego, CA
AJE Ref #
Job Classification
Full Time
Job Type
Company Ref #
Entry Level (0 - 2 years)


br strong Description /strong br P Celgeneis a global biopharmaceutical company leading the way in medical innovation tohelp patients live longer, better lives. Our purpose as a company is todiscover and develop therapies that will change the course of humanhealth.  We value our passion for patients, quest for innovation, spiritof independence and love of challenge. With a presence in more than 70countries - and growing - we look for talented people to grow our business,advance our science and contribute to our unique culture. /p P The PrincipalScientist supports Exploratory Toxicology and serves as an integral member ofthe toxicology team that supports the early stage discovery and development ofpharmaceuticals, including the identification, mechanistic investigation andmanagement of safety risk from initial Target Identification to DevelopmentCandidate nomination stages. In general, this position will provide appropriatescientific perspective to identify safety issues of a potential drug candidateearly in the drug development process.  Thisscientist will manage and supervise scientific, administrative, and technicalactivities related to In Vitro Toxicology. The Principal Scientist is alsoresponsible for assisting the San Diego Nonclinical Development management teamin establishing and achieving long-term strategic goals and tacticalobjectives. /p P strong u Responsibilities will include,but are not limited to, the following: /u /strong /P ul type="disc" li Design and conduct i in vitro /i and molecular toxicology experiments focused on identification of mechanistic basis of toxicity. /li li Evaluate and implement novel i in vitro /i toxicology models and assays /li li Conduct and manage i in vitro /i toxicology screening assays /li li Supervise and mentor scientific staff /li li Contribute to identification of early target safety risk based on projected mechanism of pharmaceutical action, literature knowledge on pathways and/or toxicological profile of competitor drugs. /li li Maintain i in vitro /i and molecular toxicology expertise through organizational associations, literature review, continuing education, and publications. /li li Establish and maintain working relationship with key opinion leaders in the toxicology community, academicians, and key Celgene staff /li li Opportunity to serve as toxicology representative on Discovery Project Teams. /li /ul P *LI-MG2   /p P *LI-PRIORITY /p P BIO-US PRIORITY /p