Purification Supervisor, Day Shift

Genzyme Corporation, ranked as one of the foremost biotechnology companies in the world, is committed to providing an exceptional environment in which individuals can excel, and achieve their professional and personal goals. Genzyme's people and culture have been consistently recognized for excellence. For example, we have been named several times to Fortune's list of the 100 Best Companies to Work For in the United States. We also consistently rank among the top employers for scientists in surveys of Science readers. Genzyme's local offices and facilities in Europe and other parts of the world have earned similar distinction as respected employers. By applying for a position with Genzyme, you are taking the first step toward becoming a part of our dynamic and talented team, and sharing in our continued success.

Manufacturing Supervisor, Protein Purification, Day Shift
Hours: 7.00AM to 7.00PM

Downstream Operations is responsible for Cerezyme protein purification operations at Genzyme's Allston Landing, a large-scale therapeutic protein manufacturing facility. Downstream Operations' main function is multi-stage large scale chromatography operations. In support of our main functions, our additional functions include, cleaning and sterilization of process equipment, preparation of bulk product for shipment and final formulation operations. This position is responsible for:Personnel ManagementLeading a manufacturing team while embodying the principles of the Genzyme Global Leadership ModelEnsuring execution of manufacturing activities in strict accordance with production batch records, standard operating procedures and CGMPMaintaining a safe working environment and reporting incidents/accidents to site leadershipManaging and developing the performance of direct reports by setting clear 'SMART' goals, providing timely performance feedback, recognizing and rewarding high achievers, and holding reports accountable for underperformanceHiring and developing new employees, conducting performance appraisals and career development assessments for all direct reports Training / ComplianceImplementing and maintaining production schedules for the Downstream Operations department while providing working knowledge of a protein purification processEnsuring Manufacturing personnel are trained to perform all assigned functions and tasksPartnering with Manufacturing Managers and Quality to ensure manufacturing areas are inspection ready at all timesEnsuring Manufacturing personnel are compliant with annual safety and CGMP trainingAdhering to applicable requirements of the consent decree ProductionOperating complex systems and equipment in strict accordance with production batch records, standard operating procedures, and CGMPUtilizing documentation control systems to author, review, and improve documentationUtilizing process knowledge and investigation skill sets to identify and resolve departmental issuesEscalating production floor issues related to procedures, materials, process, equipment, automation, utilities and/or information systems to Manufacturing Management and/or appropriate functional area(s)Adhering to site scheduling processesUnderstanding Inventory Control and ERP systems Deviation/CAPA ManagementEnsuring personnel identify and document events that deviate from procedurePartnering with Quality Assurance to detail particular deviations and complete the intake processCompleting investigations, reports, and proposes CAPA for minor deviations. Ensures on-time closure of minor deviationsSupporting major and critical deviation investigationsEnsuring on-time closure of assigned CAPA Continuous ImprovementContributing to continuous improvements of all manufacturing documentation (SOPs, MBR's, OJTs) to ensure they are current, accurate, and clear. Reviewing and refining the current document periodic review process to ensure that all Manufacturing documents re accurate and revised as necessary