Research Associate II 629786 (NCI)

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POST DATE 8/31/2016
END DATE 11/12/2016

Leidos Biomedical Research, Inc. Frederick, MD

Company
Leidos Biomedical Research, Inc.
Job Classification
Full Time
Company Ref #
360534
AJE Ref #
576029895
Location
Frederick, MD
Experience
Entry Level (0 - 2 years)
Job Type
Regular

JOB DESCRIPTION

Leidos Biomedical Research, Inc. (LBRI), a wholly owned subsidiary of Leidos, operates the Frederick National Laboratory for Cancer Research (FNLCR). FNLCR is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI). It is the only FFRDC dedicated to biomedical research. Through its status as an FFRDC, FNLCR provides NCI and others with a unique national resource to accelerate the development and delivery of effective preventive, diagnostic, and therapeutic products for cancer and AIDS.

The breadth of FNLCR s activities spans the research and development spectrum, including investigator-initiated, hypothesis-driven research into cancer and AIDS; advanced technology programs focused on genetics and genomics, proteins and proteomics, imaging, nanotechnology, bioinformatics, and laboratory animal sciences; clinical operations in support of NCI and National Institute of Allergy and Infectious Diseases (NIAID)-sponsored clinical trials, as well as NCI drug discovery and development efforts; and management and operations of biopharmaceutical development and manufacturing programs under current Good Manufacturing Practice conditions for NCI and NIAID. Administrative, procurement, financial, safety, and facilities support is provided to these R&D activities through state-of-the-art business processes. LBRI has approximately 1,900 employees and manages an annual operating budget of approximately $450M.

For more information about Leidos Biomedical Research Inc., please visit our webpage at www.leidosbiomed.com.

PROGRAM DESCRIPTION
The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.

The Protein Expression Laboratory (PEL) creates expression constructs, expresses the encoded recombinant proteins in multiple expression systems, and purifies the recombinant proteins for use in a wide variety of applications from X-ray crystallography to drug screening to biochemical analysis. PEL clients are both internal (e.g. RAS program) and external (e.g. government and private labs).

JOB DESCRIPTION
The Research Associate II will independently carry out experiments, under the review of a scientist, in the area of recombinant protein production. Responsibilities will include: 1) prokaryotic protein expression and protein purification from all expression materials, 2) may be required to develop new assays or production methods, 3) completing projects independently and as part of a team, and 4) timely updates of project progress to supervisor in both informal and formal report writing mode.

Work may involve the use of potentially hazardous chemical, biological, or radiological materials or may be located in areas where such materials are used.

May require the use of personal protective equipment and adherence to strict safety protocols.