Research Associate III - Proteomics 8/27/2016

Broad Institute Cambridge, MA

Company
Broad Institute
Job Classification
Full Time
Company Ref #
2751
AJE Ref #
575992481
Location
Cambridge, MA
Experience
Mid-Career (2 - 15 years)
Job Type
Regular

JOB DESCRIPTION

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Job Description:

The Proteomics Platform at the Broad Institute is seeking a Research Associate III/Sr. Research Associate to drive and help lead large scale efforts in the execution of protein-protein, protein-DNA and protein-small molecule interaction networks.

Affinity enrichment coupled to quantitative mass spectrometry is a powerful methodology to study protein-protein interactions and the perturbational effects of small molecule drugs. We have numerous on-going efforts to build networks in relevant cell models of cancer, infectious disease, psychiatric disease, cardiovascular disease and metabolic disorders among others and to understand the targets and the effects of drugs and drug-like molecules.

We are looking for a highly motivated scientist to drive and help lead the experimental aspects of these interactome studies. This person will be responsible for executing affinity enrichment experiments and data analysis across different projects. In doing so, they will have the opportunity to collaboratively interact with a wide range of Broad scientists with diverse backgrounds including biologists, clinicians, biochemists, chemists, bioinformaticians, and computational biologists. There will be opportunities for publication and presentation of results at conferences.

Characteristic Duties Include:

* Planning, optimization execution of affinity enrichment experiments. * Cell culture * Cloning and execution of molecular biology techniques * Operation and troubleshooting of state-of-the art LC-mass spectrometry systems. * Analysis, interpretation and presentation to collaborators of the results of mass spectrometry data. * Ensuring that data are of the highest quality. * Maintenance of metadata and records associated with sample generation and experiment execution. * Attending meetings for setting operational priorities. * Make recommendations to senior staff as to best practices and development of standard operating procedures.

Requirements:

The successful candidate will have a strong background in biochemistry and modern molecular biology techniques.

Experience with state-of-the-art proteomics and mass spectrometry is highly desirable.

The candidate must also feel comfortable with data analysis and computational methodologies.

Prior participation in multidisciplinary teams is a plus, this person will interact l with a wide variety of team members ranging from junior research associates to post-doc associates and group leaders; so strong communication skills are key.

The candidate will likely hold a Masters level degree or higher, or at least 3 years of relevant research experience in biochemistry, biology, or chemistry, although exceptions might be made for extraordinary candidates.

The Broad Institute will not offer visa sponsorship for this opportunity. EOE/Minorities/Females/Protected Veterans/Disabilities