Research Scientist Process Chemistry Scale Up Group 9/7/2016

Gilead Sciences, Inc Foster City, CA

Company
Gilead Sciences, Inc
Job Classification
Full Time
Company Ref #
34041
AJE Ref #
576107102
Location
Foster City, CA
Experience
Mid-Career (2 - 15 years)
Job Type
Regular
Education
Bachelors Degree

JOB DESCRIPTION

APPLY
SPECIFIC RESPONSIBILITIES

With the commitment and drive you bring to the PDM workplace, you will be part of a team that is changing the world and helping millions of people live healthier, more fulfilling lives. You will see the tangible results of your contributions, where every individual matters, and everyone has a chance to enhance their skills through on-going development. Our scientific focus has resulted in marketed products that are benefiting hundreds of thousands of people, a pipeline of late-stage drug candidates, and unmatched patient access programs to ensure medications are available to those who could otherwise not afford them. By joining PDM at Gilead, you will further our mission to address unmet medical needs and improve life by advancing the care of patients with life-threatening diseases.

Design and execute/run reaction sequences

Perform chemical reactions, isolations, separations, purifications, and crystallizations

Conduct route scouting, reaction optimization, and scale-up demonstration

Prepare experimental drug candidates to support pre-clinical development.

Write concise procedures and reports to enable successful technology transfers

Participate in group and project teams meetings and communicate results in a team-based environment

REQUIRED SKILLS:

The candidate must be skilled in the art and practice of modern synthetic and mechanistic organic chemistry.

Familiarity and competence with modern spectroscopic methods applied to structure determination including 1H and 13C NMR, infra-red spectroscopy, and mass spectroscopy are required.

Experience in the use of preparative silica gel chromatographic separations as well as analytical separations involving HPLC and GC.

Practical experience in multi-step syntheses is preferred.


Experience with spreadsheet programs such as Microsoft Excel and database software such as SciFinder is a plus.

Responsible for developing chemical processes for the manufacturing of drug substances.
Become familiar with kilo lab operations.

Assist in developing economical and state-of-the-art techniques to isolate, characterize, purify, and mass-produce substances under the supervision of senior scientists and/or scientific directors.

Under general supervision will plan, design, implement, and analyze laboratory experiments to help advance scientific knowledge of drug substances and or techniques to identify such substances.

- May make contributions to scientific literature and conferences through publication and presentation of research results.

Demonstrates collaborative communication and problem solving spirit.
PhD in organic chemistry or related field.

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ESSENTIAL DUTIES AND JOB FUNCTIONS

Responsible for developing chemical processes for the manufacturing of drug substances.
Familiar with Pilot Plant operations and able to write master batch records and safety summaries with limited supervision.
Pays particular attention to avoiding reactions and processes that do not scale well, such as distilling to dryness and flash chromatography.
May suggest alternative chemistry including step optimization and new route selection.
Gains a better understanding of how impurities are formed, tracked and purged throughout the subsequent processing.
Works in collaboration with more senior scientists or scientific directors to advance the development of economical, state-of-the-art techniques to isolate, characterize, purify and mass-produce substances.
Works on complex problems where analysis of situations or data requires evaluation of intangible variables, requiring regular use of ingenuity and creativity.
Advises members of project teams in the initiation and execution of laboratory experimentation, considering economic, regulatory and safety factors.
Presents results of work, interprets data, and draws conclusions regarding presented material and nature of work.
Makes contributions to scientific literature and conferences through publication and presentation of research results.
Maintains full working knowledge of state-of-the art principles and theories, applying such knowledge to the direction that supports Company interests.
Demonstrates technical proficiency, scientific creativity, collaboration with others and independent thought in suggesting experimental design and strategy.
Must think critically and creatively and be able to work independently, determine appropriate resources for resolution of problems and have strong organizational and planning skills.
Demonstrates excellent verbal communication skills and interpersonal skills.
Demonstrates collaborative communication and problem solving spirit.

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KNOWLEDGE, EXPERIENCE AND SKILLS

3+ years of experience and PhD in a relevant scientific discipline.
BS or MS degree with extensive industry experience.
If this is not the right move for you now but remain interested in a career at Gilead Sciences please connect with us via our talent community: https://gilead.avature.net/Gilead

About Gilead:
Gilead Sciences, Inc. is a research-based biopharmaceutical company that discovers, develops and commercialises innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead s therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

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As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@gilead.com for assistance.

For more information about equal employment opportunity protections, view the EEO is the Law poster at :
http://www1.eeoc.gov/employers/upload/eeoc_self_print_poster.pdf