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Research Technician

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POST DATE 8/27/2016
END DATE 2/28/2018

University of California - San Francisco San Francisco, CA

San Francisco, CA
AJE Ref #
Job Classification
Full Time
Job Type
Company Ref #
Entry Level (0 - 2 years)
Bachelors Degree



Job #JPF01078

* SCHOOL OF MEDICINE - Radiation Oncology


Open date: August 26th, 2016
Last review date: November 30th, 2016
Applications received after this date will be reviewed by the search committee if the position has not yet been filled. Final date: February 26th, 2018
Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.


The goal of our research is to understand how tissues integrate information across multiple scales of organization and to use this information in modeling critical events in carcinogenesis. We study ionizing radiation (IR), a prototypic carcinogen, in terms of its effects on cell phenotype and tissue interactions. Identifying when and how tissue alterations contribute to the action of IR may provide a means to inhibiting its carcinogenic potential, as well as a better understanding of how normal tissues suppress carcinogenesis. A major focus of my laboratory is to study the multiple and complex mechanisms by which transforming growth factor beta (TGF ) affects irradiated cells and tissues. The combined effects of TGF and IR have profound effects on epithelial phenotype, centrosome regulation and genomic stability.

The successful candidate will work with a faculty PI in the Department of Radiation Oncology at UCSF and postdoctoral fellows and staff in support of studies to investigate the response of cancer and normal cells to TGF and ionization radiation using cultured cell and in-vivo preclinical models. S/he may also assist in maintaining laboratory stock and supplies as well as monitor/maintain lab equipment and instruments. The candidate should be able to work independently under the direct supervision of the PI or lab manager and also as part of a team.

We have and will continue to have one of the most technologically sophisticated departments in the world. More importantly we pride ourselves on our ability to use this technology appropriately. Our mission includes excellence in teaching, research and most importantly patient care. We are committed to educating our residents and fellows to be future leaders in radiation oncology and we have an outstanding track record in this regard. Some of the most important national studies in radiation oncology have been conducted here, and we continue to seek new approaches proven to benefit our patients.

The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It is the only campus in the 10-campus UC system dedicated exclusively to the health sciences.

Required Qualifications:

* A college baccalaureate degree in the biological sciences is required.

* Previous experience in a wet laboratory setting and strong familiarity with techniques such as ELISAs, immunohistochemistry, microscopy, cell culturing, and other molecular and cell-based assays.
* Required technical skills may include Cell Culture: maintaining cell lines, transfection techniques, and establishing clonal cell lines.

* Required molecular and genetic techniques include PCR and qPCR, Western Blot, Gel Electrophoresis and Protein expression, DNA/RNA isolation, Plasmid DNA preparation, and Bacterial transformation.

* Strong written and verbal communication skills are required. The technician will be responsible for maintaining accurate, written records of their work.

* The candidate must also satisfy all required departmental and hospital regulatory compliance including HIPPA, health and biosafety training, as well as pass medical clearance from the UCSF employee health center if needed to work with animals. The applicant must also be currently authorized to legally work in the United States.

Preferred Qualifications:

* Experience with flow cytometry/FACS sorting and analysis is highly desired.

* Familiarity with CRISPR/Cas9-mediated gene expression technology

* Small animal handling, measurement, and husbandry experience. We will help train the selected candidate based on our protocols. The successful candidate may also assist in minor animal surgeries and other techniques such as tissue collection and histology preparations.

* Prior UCSF knowledge especially with the UCSF animal facility and system is highly desired.

Salary and rank will be commensurate with the applicants experience and training.

The term of the position is for 1 year from the start date. The option to extend the appointment by the PI is strictly based on availability of future funding and performance and cannot be guaranteed.

The University of California San Francisco is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, or protected veteran status. Further information about the University of California, San Francisco, is available at UCSF seeks candidates whose skills, and personal and professional experience, have prepared them to contribute to our commitment to diversity and excellence, and the communities we serve.

Please apply online at


San Francisco, CA


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