SRA, Analytical Chem
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POST DATE 9/18/2016
END DATE 10/23/2016
DiCE Molecules Corporation
Redwood City, CA
JOB DESCRIPTIONExciting opportunity in an early-stage startup focused on DNA programmed chemical synthesis to enable the discovery and evolution of small molecules for pharmaceutical applications.
We have an opening for exceptional candidates with a strong background in analytical chemistry at the Sr Research Associate/Associate Scientist level. Key skills include expertise in HPLC chromatography and mass spectrometry. The candidate s primary responsibilities will include development and execution of LCMS analytical methods for chemically modified DNA oligonucleotides to support the development of diverse chemical libraries. The successful candidate will collaborate closely with the Chemistry team to design experiments and provide critical data for decision-making. Critical, scientific evaluation of all data to ensure that appropriate conclusions are drawn is essential. Experience with Agilent LCMS hardware and software and/or MS of proteins or oligonucleotides would be advantageous. Familiarity with additional analytical techniques utilized in biotechnology research and with the use of electronic laboratory notebooks would be advantageous.
Development of LC methods for small molecules as well as DNA oligonucleotides
Evaluation of alternative mobile phases and columns to improve sensitivity and resolution
Sample analysis including processing of analytical data to support research
Routine support and troubleshooting of LCMS instruments and coordination with service professionals as necessary
Preparation of summaries, reports and presentations
Development and execution of preparative chromatography methods as needed
Develop new and creative approaches