#81804 Staff Research Associate II - Cancer Center
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POST DATE 9/3/2016
END DATE 11/17/2016
University of California - San Diego Medical Centers
San Diego, CA
JOB DESCRIPTIONAPPLY This position will remain open until a successful candidate has been identified.
UCSD Layoff from Career Appointment or Special Selection: Apply by 5/9/16 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor. Eligible ACCES or Special Selection clients should contact their Vocational Rehabilitation Counselor for Special Selection.
The Cancer Center is an NCI-designated Comprehensive Cancer Center one of only 40 nationwide. As such, it ranks among the top centers in the nation conducting basic and clinical cancer research, providing advanced patient care and serving the community through outreach and education programs. The Cancer Center maintains a membership roster of 342 faculty members whose academic appointments are in 18 different departments which often creates complex, unique and one of a kind insurance situations.
The Staff Research Associate II (SRA) will carry out independent research under the supervision of the lead project scientist and assist in preparing research plans, developing and performing new research techniques, and troubleshooting new and established assay techniques. The SRA assists in planning, designing, performing and analyzing in vivo and in vitro experiments to study expression of receptor tyrosine kinase like orphan receptor 1 (ROR1) in ovarian, breast, and pancreatic cancer stem cells and to define role of ROR1 in promoting tumor growth, metastasis, and tumor initiation using primary cancer cells and cell lines. Conduct pre-clinical study of anti-ROR1 mAb alone in combination with other agents or mAb-drug conjugates (ADC) human breast, ovarian, colon, pancreatic and other orthotopic xenograft mice model. Perform pharmaceutical kinetic and pharmaceutical dynamic study for anti-cancer drugs. Must have extensive experience working with animals and flow cytometry.
Theoretical knowledge of immunology, molecular biology, cell biology, cancer stem cell and/or protein chemistry as generally acquired through a bachelor's degree and/or equivalent education and/or experience.
Practice in caring for and handling small lab animals and in administering medications and anesthesia to perform phlebotomy and minor surgical procedures on animals. Practice with euthanizing small laboratory animals. Familiarity with the writing of Animal Subjects protocols and with the surgical procedures. Willingness and ability to work with rodents and/or other lab animals and/or infected samples.
Experience to perform PK/PD studies on anti-cancer pharmacological agents.
Strong knowledge and experience in flow cytometry and operation of a FACSCalibur instrument. Design, perform, and interpret results from experiments with human and mouse cells stained with specific fluorochrome-conjugated monoclonal antibodies.
Experience with culturing primary tumor cells, cancer cell lines and cancer stem cells in vitro and developed expertise in molecular cell biology techniques.
Excellent interpersonal and oral communication skills. Demonstrated skill to effectively and clearly communicate with tact, diplomacy, discretion, and flexibility to faculty, academicians, students, and staff including those of diverse ethnicity, culture, and foreign nationals. Ability to present information clearly and concisely.
Knowledge of various cell based assays pertaining to investigating cancer stem cell hypothesis.
Excellent organizational skills to order and maintain lab equipment and order supplies.
* Knowledge of the cancer stem cell hypothesis and markers, particularly as it pertains to ovarian cancer, breast cancer, and pancreatic cancer.
* Must be willing to work with rodents and hazardous and bio-hazardous materials.