Scientist, Global BioTherapeutics 8/20/2016

A New Beginning - Genesis 2 Framingham, MA

Company
A New Beginning - Genesis 2
Job Classification
Full Time
Company Ref #
28889725
AJE Ref #
575946218
Location
Framingham, MA
Job Type
Regular

JOB DESCRIPTION

APPLY
SCIENTIST, GLOBAL BIOTHERAPEUTICS

The Global BioTherapeutics Division of this Company is looking for a strong technical/scientific leader in biophysics and formulation of liquid drug products of high protein concentrations. Minimum requirements are a Ph.D. in biochemistry, protein biophysics, protein chemistry, biochemical engineering, physical chemistry or pharmaceutical sciences with 0-3 years of experience in formulation, delivery, and combination product development of biologics including monoclonal antibodies, bi-specific and tri-specific molecules and peptides.

RESPONSIBILITIES:

* Develop the fundamental understandings of the links between molecular structure/solution compositions and macroscopic behavior including rheology, phase transition, and aggregation propensity in bulk solutions and at interfaces.
* Develop the state-of-the-art techniques to measure the rheological behavior of protein solutions to probe both bulk and interfacial properties for guiding the development of drug device combination development.
* Work closely with Global Biologics Research organization to establish the correlation between protein structure and solution behavior.
* Develop innovative formulation technologies for optimizing solution compositions to overcome the practical challenges encountered during the development and commercialization of drug device combination products.
* Be the advocates of rheological science of biologics drug products at our company. Build close connection to the academic/private eco-system to incorporate the best practice into our company''s drug device development tool boxes.

BASIC QUALIFICATIONS:

PH.D. in biochemistry, protein biophysics, protein chemistry, biochemical engineering or pharmaceutical sciences with 0-3 years of experience in the biopharmaceutical industry.

PREFERRED QUALIFICATIONS:

* Expertise in high concentration protein formulation technologies and the associated biophysics, rheology, and applied thermodynamics/kinetics including in particular: protein-excipient interactions, protein-devices characterization/optimization; thermodynamic of liquid-liquid phase separation in proteins; protein-protein interactions advanced knowledge in sedimentation equilibrium and sedimentation velocity analysis of proteins as well as light scattering, thermodynamic and kinetics modeling of high protein concentration self-association pathways; formulation inject ability.
* Hands-on experience with interfacial & bulk rheometry, UV-vis and FT-IR spectroscopy, circular dichroism.
* Good awareness of emerging and exploratory approaches in the fields of stabilization of high concentration protein solutions and optimization of solution behavior for development drug device combination products.

COMPENSATION
Base Salary - $95,000 to $120,000
Benefits - Full
Relocation Assistance Available - Possible for ideal candidate
Bonus Eligible - Yes

CANDIDATE DETAILS
2+ to 5 years experience
Minimum Education - Doctorate Degree
Willingness to Travel - Occasionally

Also, please understand this may take time for both of us working together to help advance your career. I will do my best for you and never charge you anything for our time and efforts.