September 03, 2016

Scientist I-III, Biomarker and Clinical Diagnostic Development

Five Prime Therapeutics, Inc. - South San Francisco, CA

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Job Description

div id="contentwrapper" p strong Five Prime Therapeutics, Inc.  /strong (NASDAQ: FPRX) is a publicly traded, clinical-stage biotechnology company focused on discovering and developing innovative immuno-oncology protein therapeutics for patients with serious unmet medical needs. Five Prime has entered into strategic collaborations with leading global pharmaceutical companies and has promising product candidates in clinical and preclinical development. /p p We currently have three protein therapeutics in clinical trials: /p ul li FPA008: a monoclonal antibody that inhibits the CSF-1 receptor and is being studied in multiple tumor settings and pigmented villonodular synovitis (PVNS) /li li FPA144: a monoclonal antibody targeting FGFR2b for selected gastric cancers /li li FP-1039: a FGF ligand trap for mesothelioma /li /ul p On the strength of our unique discovery platform and capabilities, we have entered into strategic collaborations with leading global pharmaceutical companies.  We currently have three active research collaborations with Bristol-Myers Squibb, GlaxoSmithKline and UCB Pharma, S.A. /p p Five Prime is committed to innovation and outstanding science to develop effective new drugs for the treatment of severe diseases. These values are reflected in our people and our products. We value our culture of openness, collaboration and productivity. Discover more about FivePrime at /p h2 Position /h2 p This is a unique opportunity for a highly-motivated scientist to join a team of pathologists, translational scientists, and technologists to design and implement complex experiments, and analyze data to support ongoing biomarker efforts in clinical and non-clinical programs at FivePrime. The ideal candidate will play an important role by applying state of the art technologies to analyze biological specimens, and by designing, developing and integrating innovative technologies, while closely interacting with project teams. The successful candidate will be responsible for designing and performing multiplexed immunohistochemistry (IHC), immunofluorescence (IF), in situ hybridization (ISH) assays and data analysis. Performing other tissue-based molecular pathology approaches such as DNA/RNA profiling are also envisaged to elucidate target prevalence, mechanism of action, and pharmacodynamics to guide the development of new drugs to treat human cancers. /p h2 Essential Job Functions /h2 p The primary responsibilities include, but are not limited to: designing complex quantitative pathology assays, and implementing new technologies to address key questions about our therapeutic candidates. Responsibilities will include: /p ul li Develop and implement tissue-based biomarker strategies to support drug development efforts /li li Develop tissue-based and fit-for-purpose assays, validate and optimize antibodies /li li Perform routine manual and automated IHC, IF and ISH, plus other molecular pathology techniques as needed. Perform other supportive functions such as pathology slide digitization and construction of tissue microarrays, contribute to evaluation of TMA results /li li Process cell pellets, human and animal tissues /li li Provide comprehensive decision-enabling reports as needed /li li Participate in meetings, discuss and provide feedback to project teams /li li Standardize workflow and reports /li li Will learn and help implement new technologies as needed /li /ul