Scientist II - In Vivo Pharmacology
Merck & Co., Inc. - Boston, MA
This job is no longer active. View similar jobs
Serve as Research Biologist in the In Vivo Pharmacology Department working within the oncology animal model development & implementation team performing experiments using preclinical species to evaluate in vivo efficacy, tolerability and or pharmacokinetic/pharmacodynamic activity. Responsibilities include contributing to experimental design and developing detailed in vivo work plan/experimental protocols; executing in vivo studies to research tolerability and efficacy of both monotherapy and combination therapy oncology agents; entering data, analysis, and interpretation into appropriate notebook and/or database; working collaboratively within department and across departments; investigating pharmacokinetic and pharmacodynamic parameters and correlation to efficacy response; managing external studies including implementation, defining protocols, monitoring execution and ensuring finalization of studies within set timelines; and ensuring all samples generated from external in vivo studies are analyzed and/or stored where necessary and that data is appropriately recorded. REQUIREMENTS: Must have Master’s Degree in Biochemistry, Pharmacology, or Translational Medicine, and 3 yrs of industry experience as an in vivo scientist. Experience must include utilizing pharmacological/physiological and surgical techniques in small animal species; using pharmacological tools in preclinical animal models to evaluate in vivo efficacy and tolerability (including study design, animal handling, dosing via numerous routes, blood and tissue sampling and data collection analysis and interpretation); performing studies to identify biomarkers as predictive indicators of compound efficacy through sampling of blood, tissue and CSF and correlate PK/efficacy responses in mouse and rat; performing in ex vivo and in vitro techniques for PD profiling of novel chemical entities; managing external projects, including study design, data and sample management; and understanding and implementing applicable regulations around animal care/safety/handling.