Senior Manager, Cancer Cell Line Factory Program Execution 9/17/2016

Broad Institute Cambridge, MA

Broad Institute
Job Classification
Full Time
Company Ref #
AJE Ref #
Cambridge, MA
Mid-Career (2 - 15 years)
Job Type
Masters Degree


Job Description:

The Broad Institute of Harvard and MIT is looking for an exceptional candidate for a unique position as the Senior Manager for the Cancer Cell Line Factory (CCLF) project ( This position affords the exciting opportunity to be part of a new and rapidly growing research effort at the Broad Institute aiming to create hundreds of new models of cancer each year directly from patient samples, with full genomic and clinical characterization, to fuel the study of cancer dependencies at scale. Since the paucity of cell line models has severely blunted research in cancer, achieving this project goal will catalyze new directions in biomedical research with potential for global impact.

The CCLF project is collaboration involving over 50 individuals and 20 laboratories that depends on extraordinary coordination between laboratory and clinical sites. This individual will be responsible for working with clinical colleagues to establish and refine robust local, regional, national and international biospecimen acquisition pipelines. He/she will travel locally to clinical sites and work closely with hospital staff to ensure biospecimen and clinical data are acquired on pre-approved timelines. He/she will also partner closely with the Laboratory cell model derivation team at the Broad Institute to ensure that milestones and timelines are met and that results and issues are promptly communicated back to clinical collaborators and external partners. Overall, Program risk identification and mitigation will be a primary responsibility.

He/she will coordinate new direct-to-patient online sample acquisition projects that have been recently launched in collaboration with external research foundations and internal Broad teams. Throughout, relationship management (with scientists, clinicians, funders and patients) will be a primary focus.

In addition, the successful candidate will work closely with compliance and regulatory and business development teams to optimize inter-institutional alignment and patient protection. He/she will work closely with external funding agencies to track project progress, prepare milestone reports and ensure that milestones are achieved. Critically, he/she will identify problems and bottlenecks and propose and implement solutions. The successful candidate is expected to work in close collaboration with the CCLF Operations and Scientific Leaders, trainees, computationalists and Project Principal Investigators, but work largely independently on a daily basis after training.

The Broad Institute provides a vibrant research environment with close links to top academic institutions across the Boston Area and provides the potential for your contributions to be used and recognized worldwide.


* Coordinates with clinical research coordinators, pathologists and technicians from a diversity of clinical sites to acquire high quality biospecimens on approved timelines; identifies and solves sample-sourcing bottlenecks;

* Works closely with laboratory team to compile scientific reports, set priorities, milestones and evaluate scientific progress; helps to track in real-time project dependencies; identifies and migrates potential risks;

* Manages external relations by designing and implementing outreach, tracking and reporting solutions for clinical investigators, collaborators, funding agencies and other project partners; ensures that the status of cell models and their validation is communicated back to partners in a clear and timely manner.

* Works closely with others to ensure that the IRB consent process is optimized for both well-studied as well as underrepresented populations and that MTA and intellectual property inter-institutional negotiations are completed efficiently;

* Identifies problems and/or inconsistencies, suggests and implements iterative improvements.

* Prepare oral presentations and written reports and analyses setting forth progress, trends and appropriate recommendations or conclusions;


* Communication and relational skills. The candidate must effectively discuss issues and negotiate and influence others and explain goals and decisions to different groups.

* Decision-making skills. The candidate must logically assess different options and recommend the best course of action with group.

* Management skills. The candidate must be able to manage a complex initiative with multiple moving components.

* Scientific skills. The candidate will be expected to make major intellectual contributions to the overall strategy and scientific deliverables of the Program.

* Problem-solving skills. The candidate must be able to proactively anticipate issues before they arise, recognize shortcomings and effectively carry out solutions.

* Time-management skills. The candidate must be able to perform multiple tasks at the same time to ensure that the project meets deadlines and goals.


* MS or PhD degree in Biology/Molecular biology/Biochemistry/Cancer research or related field required

* 3 years experience with laboratory science, and/or cancer genomics is required. Experience generating patient-derived cellular models is a plus.

* Experience managing complex, inter institutional projects with complex milestones, including those with regulatory, clinical components

* Experience interacting with governmental agencies is a plus.

* Strong track record of scientific publications and achievements.

* Ability to work independently and in cross-functional teams.

* Excellent oral, written and interpersonal communication skills.

EOE / Minorities / Females / Protected Veterans / Disabilities