Senior Research Associate, In Vivo Pharmacology Discovery Biology
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POST DATE 9/8/2016
END DATE 10/13/2016
San Francisco, CA
JOB DESCRIPTIONAPPLY Nurix, Inc. is a science-minded, goal-oriented organization that is focused on bringing novel, first-in-class therapies to patients. Nurix is a leader in discovering a new class of drugs that work by modulating the protein degradation machinery of the cell. The Nurix scientific team has established an innovative drug discovery platform based on recent advances in understanding of the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein stabilization and degradation, a function vital to the healthy life of a cell, uncovering therapeutic opportunities in multiple disease areas.
Nurix s Protein Regulation Platform enables the discovery of selective inhibitors or activators of the UPS, enabling the discovery of new class of drugs that can restore normal cellular homeostasis. In September 2015, Nurix entered into an exclusive collaboration with Celgene for the discovery and development of next-generation therapies targeting protein homeostasis in oncology, immunology and inflammation, including the rapidly evolving field of immuno-oncology.
Nurix was founded by internationally recognized experts in the ubiquitin proteasome field and is funded by leading life science investors, Third Rock Ventures and The Column Group. The company is headquartered in San Francisco, California
We are seeking a highly skilled and motivated Senior Research Associate to support Nurix s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology. The ideal candidate will have expertise in small molecule PK/PD and efficacy studies in oncology or immuno-oncology. This individual will work closely with our drug discovery project scientists on late-stage lead optimization of novel compounds to support dose and schedule optimization, demonstrate vivo efficacy, and characterize ex vivo immune cell function. The candidate must be self-driven, organized, able to work well with project scientists, and able to thrive in an exciting environment in a rapidly-growing company.