Senior Research Scientist

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POST DATE 9/19/2016
END DATE 10/15/2016

Dole Kannapolis, NC

Kannapolis, NC
AJE Ref #
Job Classification
Full Time
Job Type
Company Ref #
Entry Level (0 - 2 years)


Job Description:

GENERAL DESCRIPTION / PRIMARY PURPOSE Dole Food Company is the largest supplier of fresh fruits and vegetables in the world and the Dole Nutrition Institute (DNI) is considered a leader in both nutrition research and consumer education. A diet rich in fruits and vegetables is essential to a normally functioning human metabolism but little is known about the influence of phytochemicals on this metabolism and thus the role they may play in human health. The successful candidate will investigate how phytochemicals interact with, and effect changes in, the gene expression associated specifically with our own endogenous antioxidant based protection mechanisms otherwise known as the Antioxidant Response Element (ARE). As Senior Research Scientist of the newly formed Dole Human Metabolism Lab the successful candidate will design and carry out studies to illustrate this interaction. Working closely with the Dole Analytical Chemistry Lab the two groups will identify which phytochemicals are absorbed, what they are transformed into and what forms they may take when possibly interacting with our innate ARE. The position will also coordinate with NCRC university partners to assist in designing Dole funded clinical trials to demonstrate these perceived health benefits. The expectation is that this information will be published in peer reviewed scientific journals, adding to the platform of evidence underpinning why fruits and vegetables are healthy for you. The position will report directly to the VP, Nutrition Research and Director of the Dole Nutrition Institute (DNI) and will be based in the Dole Nutrition Research Laboratory located within the Plants for Human Health Institute (PHHI) at the North Carolina Research Campus (NCRC), Kannapolis, North Carolina. MAJOR RESPONSIBILITIES AND TASKS/DUTIES OF THE POSITION Investigate the interactions of bio-actives, found in fruits and vegetables, on the various endogenous antioxidant protection mechanisms in human metabolism. Coordinate assigned collaborative research projects with North Carolina Research Campus university partners as proof of action in humans. Supervise and coordinate the work of a post-doctoral student attached to NC State's PHHI. Design experiments; develop and perform in-vitro and cell based-assays towards the identification of ARE gene expression, biomarkers of expression; interpret data and maintenance of detailed records of experimental observations. Experience working independently and with a team to prepare study-related documents, including Institutional Bio Safety Committee (IBC) and Environmental Health & Safety (EHS) applications. Highly proficient in a broad range of molecular and biochemical techniques including cell culture, cryopreservation, cytotoxicity assays, phase and fluorescent microscopy, RT-PCR, qPCR. Strong analytical and instrumentation skills including HPLC, LC-MS and GC-MS. Preparation of written protocols and communication of results in technical reports. Learn new investigative techniques for future nutrition research and suggest new projects to illustrate the health benefits of fruits and vegetables in humans. Survey the current scientific literature to keep abreast of nutrient analysis and nutrition research updates and develop/adapt methods to assist with ongoing research projects. Attend seminars/workshops to broaden knowledge of NCRC-based research activities. Additional duties as assigned.