Senior Scientist, DNA Encoded Chemistry, Library DIscovery
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POST DATE 9/3/2016
END DATE 11/2/2016
San Francisco, CA
Nurix, Inc. is a science-minded yet goal-oriented organization that is focused on bringing novel, first-in class therapies to patients. Nurix is a leader in discovering a new class of drugs that work by modulating the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein stabilization and degradation, a function vital to the healthy life of a cell, uncovering therapeutic opportunities in multiple disease areas. The Nurix scientific team has established an innovative drug discovery platform to enable the discovery of selective inhibitors or activators of the UPS, enabling the discovery of new class of drugs that can restore normal cellular homeostasis. Nurix entered into an exclusive collaboration with Celgene for the discovery and development of next-generation therapies targeting protein homeostasis in oncology, immunology and inflammation, including the rapidly evolving field of immuno-oncology. Nurix was founded by internationally recognized experts in the ubiquitin proteasome field and is funded by leading life science investors, Third Rock Ventures and The Column Group, and recently entered into a multi-year strategic collaboration with Celgene. The company is based in San Francisco, California.
About the Position
We are seeking a talented and highly motivated Scientist with a strong background in synthetic organic chemistry and DNA encoded chemistry to lead our library group in the pursuit of novel small molecules to treat patients with unmet medical needs. Specifically, this individual will lead a small group whose primary focus will be to design and synthesize DNA encoded libraries and utilize these libraries to identify novel chemical matter with the potential to modulate our key targets. The successful candidate will have demonstrated experience in evaluating and prioritizing chemical features from affinity selection experiments. A key responsibility will be to integrate with the existing medicinal chemistry team to rapidly scan outputs for drug-like hits that can be further optimized for potency, selectivity, pharmacokinetics and in vivo efficacy. As a member of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix as well as with external collaborators. Additionally, they will contribute effectively to patent, report and scientific publication writing.