Senior Scientist - Mechanistic Biochemistry

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POST DATE 8/21/2016
END DATE 10/29/2016

AstraZeneca Pharmaceuticals LP Waltham, MA

Waltham, MA
AJE Ref #
Job Classification
Full Time
Job Type
Company Ref #
Entry Level (0 - 2 years)


At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe. As Senior Scientist - Mechanistic Biochemistry in Waltham, MA you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives. IMED (Innovative Medicines and Early Development) focuses on scientific advances in small molecules, oligonucleotides and other emerging technologies and drug discovery platforms across our focus areas. Discovery Sciences is a multi-faceted department which drives early drug discovery across the global Innovative Medicines portfolio (small molecule and biologics). br br The Screening Sciences group is a multidisciplinary department within Discovery Sciences. This group has responsibility for compound management; biochemical reagent generation, assay development, plate based hit identification and compound profiling, and mechanism-of-action studies primarily in support of the Oncology and Neuroscience Innovative Medicines portfolio. The group is focused on delivering enhanced quality small molecule leads for enzyme and protein:protein interaction discovery projects, using primarily Biochemical assay platforms in conjunction with protein mass spectroscopy. br br Main Duties and Responsibilities br br As a Senior Scientist in Screening Sciences, you will serve as mechanistic enzymologist, possessing skills in bioanalytical and biophysical techniques such as the use of surface plasmon resonance (SPR/Biacore) for understanding enzyme and small molecule inhibitor mechanism and protein interactions. In addition you will be expected to contribute to our understanding of cellular mechanisms of small molecule action, working with the Discovery Sciences Chemical Biology Team. You are expected to be a scientific leader and be able to represent the discipline across a broad range of therapeutic projects and global initiatives within Discovery Sciences and iMED br br In this role, you will provide guidance for enzyme and protein:protein interaction related projects across the Oncology and Neuroscience iMED portfolios, relating to protein biochemistry, hit and lead identification, kinetics, mechanism of action and toxicity mechanisms, acting as Discovery Science contact for one or more therapeutic projects. You will establish best practice for screening or profiling of enzyme and protein:protein interaction targets, working with colleagues to provide analysis of kinetic and mechanistic assays. br br br br