Senior Scientist, Translational Medicine

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POST DATE 9/14/2016
END DATE 10/12/2016

Celgene San Francisco, CA

Job Classification
Full Time
Company Ref #
San Francisco, CA
Entry Level (0 - 2 years)
Job Type
AJE Ref #


br strong Description /strong br P Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing we look for talented people to grow our business, advance our science and contribute to our unique culture. /p P strong u Summary/Scope /u /strong /p P Reporting to Principal Investigator, Translational Development, the candidate will contribute to developing strategy and be responsible for experimental design and execution of translational research studies supporting oncology drug development programs from discovery through early clinical development.  This individual will also have the opportunity to provide translational support to clinical development teams, to implement biomarker programs and analyze patient data.  The successful candidate will have research experience in cancer biology with an emphasis in immune-oncology and development and evaluation of oncology therapeutics. /p P strong   /strong /p U strong br /strong /U U strong Responsibilities will include, but are not limited to, the following: /strong /U P •Develop strategy, design, execute and interpret experiments to define dose-schedules, patient selection markers and other biomarker readouts, combination strategies and pathways of drug resistance for oncology programs  /p P •Use cell-based assays and molecular and biochemical profiling to characterize drug mechanism of action, cellular mechanisms of efficacy, and rational drug combinations /p P •Lead scientifically on cross-functional and cross-site teams /p P •Interact with project teams, academic collaborators and contract laboratories to design in vitro and in vivo studies to evaluate drug candidates /p P •Develop and review study proposals, manage relationships and critically review data from contract labs and academic collaborators /p P •Evaluate and advise on clinical trial biomarker/exploratory endpoint strategies, collect and analyze patient data to inform clinical development /p P •Present work at group meetings, internal forums and scientific conferences /p P •Author study reports, assay protocols, patent applications, peer-reviewed publications /p P •Potentially mentor other research staff through instruction, coaching and guidance /p P strong u Functional/Scientific/Technical Skills: /u /strong /p P • Contributing to research program and business. /p P • Subject matter leader. /p P • Broad knowledge of multiple functional technologies. /p P • In-depth understanding of function as it relates to project. /p P • Leads by example in lab. /p P • Functional area expert with skills, theoretical knowledge and experience to apply scientific direction and approach to projects and problems. /p P strong u Tasks and Responsibilities: /u /strong /p P • Completes technical assignments by designing, executing and interpreting complex experiments. /p P • Recommends department level strategic decisions. /p P • May lead scientifically on cross functional assignments. /p P • Manages and/or coordinates workflow on projects. /p P • Apply diverse scientific knowledge to assignments. /p P • Development of research tools. /p P • Interpret results. /p P strong u Discretion/Latitude: /u /strong /p P • Helps design research strategies consistent with department goals. /p P • Provides input and makes recommendations to research strategies. /p P strong u Creativity and Problem Solving: /u /strong /p P • Identify & solve multi-faceted challenges. /p P • Recognizes problems and is able to recommend and develop appropriate solutions from prior experience, literature, or collaboration. /p P • Identify risks. /p P • Contributes ideas and develops/presents a scientific case (or position) inside and outside department/group. /p P strong u Teamwork and Influence: /u /strong /p P • Communicates with cross functional team. /p P • Directly impacts the achievement of workgroup/team goals. /p P • Represents workgroup/team or department on multi-disciplinary or cross functional teams. /p P • Work across departments. /p P strong u Organizational Impact: /u /strong /p P • Direct impact on departmental performance. /p P • Impact is achieved by driving team efforts. /p P • Able to conceptualize broad impact of research programs and personal activities in terms of site. /p P strong u Behavioral Competencies: /u /strong /p P • Champions change  /p P • Leads courageously /p P • Networking  /p P • Provides directions /p P • Structuring and staffing /P P • Thinks strategically /p br br *LI-JW1 *LI-PRIORITY br br strong BIO-US                                   /strong br