Sr. Research Associate, Biochemistry/Enzymology
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POST DATE 9/16/2016
END DATE 10/17/2016
Edison Pharmaceuticals, Inc.
Mountain View, CA
JOB DESCRIPTIONEdison Pharmaceuticals is seeking an independent and motivated research associate in biochemistry with at least 10 years prior pharmaceutical/biotech experience including protein biochemistry, enzymatic assay development and kinetic characterization of enzymatic reactions. The candidate will assist in the mechanistic and biochemical characterization of oxidoreductase enzymes involved in energy metabolism and regulation. The candidate s primary responsibilities will include performing, troubleshooting and transferring assays supporting discovery, target engagement and mechanism of action studies. The ideal candidate will be familiar with working in an anaerobic glovebox/controlled atmosphere environment. The candidate is expected to be able to participate in inter-disciplinary discovery projects in an innovative and fast-paced team environment.
Develop and implement a variety of low-to medium throughput assays using purified proteins and cellular lysates to characterize small molecule interactions with potential targets
Assist in creating standard procedures for developed assays and aid in transfer of selected assays to high throughput format
Perform routine enzymatic activity assays and maintain written and electronic records of kinetic information including activity controls for cross-dataset normalization
Collaborate with cell/molecular biologists and medicinal chemists to develop small molecule enzyme structure-activity relationships
Interpret data and summarize key findings from R&D studies in support of target validation hypotheses