Associate Principle Scientist, PDX Model Team Lead, Oncology Biosciences

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POST DATE 10/8/2017
END DATE 11/5/2018

AstraZeneca Pharmaceuticals LP Waltham, MA

Waltham, MA
AJE Ref #
Job Classification
Full Time
Job Type
Company Ref #
Mid-Career (2 - 15 years)
Doctoral Degree


b Location: /b Waltham, br Massachusetts, br United States br b Job reference: /b R-015130 br br b Posted date: /b Oct. 05, 2017 p b u Associate Principle Scientist, /u /b b u PDX Model Team Lead /u /b b u , Oncology Biosciences /u /b /p p At b AstraZeneca /b , we work together across global boundaries to discover, develop, manufacture and market prescription medicines that make a positive impact on the lives of patients as well as their families and communities. At AstraZeneca Oncology, our vision is redefining cancer, redefining our solutions to cancer and restoring patients' lives. Our mission is to make a meaningful difference to patient health through great medicines that bring benefit for patients and add value for society. /p p In addition to our passion for the discovery of innovative new medicines, we understand the importance of flexibility in our work-life environment and we offer a wide variety of benefits, services and programs that provide our employees the resources they need to pursue not only their work goals but also their life goals. We are dedicated to building strong research teams that embrace the diversity of talents of team members and allow the larger group to grow and learn together to accomplish our collective goal to improve human health. /p p b u Description: /u /b /p p As an b Associate Principle Scientist, /b b PDX Model Team Lead /b you must be a highly motivated i in vivo /i pharmacologist with a strong background generating and using patient-derived xenograft (PDX) models of cancer in an industry setting. You will use your expertise to lead the PDX model team based in our state of the art BioHub facility in Waltham MA. /p p b u Key Responsibilities: /u /b /p ul li Provide both strategic and hands-on leadership of the PDX model capability build within the Oncology i In Vivo /i Bioscience team. /li li Lead a team to establish banks of “study-ready” tumor fragments for routine use by project teams, including models representing aggressive cancers from patients progressing on therapies. /li /ul ul li Work with external providers, clinical researchers and government-sponsored respositories to aggressively grow our internal model bank. /li li Evaluate emerging technologies to enable routine PDX model development from limited tissue biopsies, including FNAs. /li li Manage all aspects of model characterization, and work with a cross-discipline global team to devise solutions for data storage and retrieval to enable broad use across the oncology R&D organization. /li li Drive the strategy for ex vivo drug testing in PDX models. /li li Support the growth of our early portfolio by using PDX models to identify new drug targets /li /ul p b u Minimum Requirements: /u /b /p ul li PhD with a minimum of 7 years relevant experience, including experience in Biopharma. /li li Demonstrated expertise generating and working with PDX models, including PK/PD, efficacy and biomarker studies to inform patient selection strategies, dose and schedule optimization, and identify rationale drug combinations. /li li Broad experience developing and working with complex i in vivo /i models, including surgical and humanized models of cancer. /li li Strong track record of working across boundaries to deliver common goals. /li li Ability to lead from the bench in problem solving and the development of innovative solutions. /li li Excellent communication and presentation skills /li li A proven track record of high productivity and scientific publications in peer reviewed journals. /li /ul p b u Next Steps – Apply today! br /u /b /p ul li b AstraZeneca /b is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity. /li /ul ul li To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them. /li /ul ul li i AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised. br /i /li /ul