PostDoc Fellow - Differentiating the effects of myeloid-targeting drugs on the tumor microenvironment by single cell

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POST DATE 2/20/2017
END DATE 4/23/2017

AstraZeneca Pharmaceuticals LP Waltham, MA

Waltham, MA
AJE Ref #
Job Classification
Full Time
Job Type
Company Ref #
Entry Level (0 - 2 years)


div class="overview-left" div class="job-location job-info" b Location: /b Waltham, Massachusetts, United States br /div b Job reference: /b R-003859 br br b Posted date: /b Mar. 10, 2017 br br ul style="margin-top:40px;" /ul /div br br div class="ats-description" itemprop="description" p At AstraZeneca we believe in the potential of our people and you’ll develop beyond what you thought possible. We make the most of your skills and passion by actively supporting you to see what you can achieve. We need great people who share our passion for science and have the drive and determination to meet the unmet needs of patients around the world. If you’re curious about what science can do, then you’re our kind of person. /p p Cancer is one of the greatest challenges facing medical science today. In our Oncology Team, you’ll push the boundaries of science every day to overcome that challenge. We’ve been at the center of some of the biggest breakthroughs in oncology. In lung cancer, for example, we’ve brought together complementary expertise to aid discovery and accelerate development in new medicines through a variety of partnerships and initiatives. We’re also early adopters of new technologies to support innovation, including CRISPR, genome editing techniques and a next-generation sequencing platform for companion diagnostics in oncology. But we’re not stopping there. With a world-class pipeline and some of the best experts in the industry, we’re in a great position to develop even more innovative therapeutic approaches. br /p p b Main duties and responsibilities /b br /p p Immunotherapy is changing the paradigm for the treatment of cancer. Myeloid-targeting drugs have the potential to decrease immunosuppression in the tumor microenvironment (TME), thereby enhancing the activity of recently approved immune checkpoint blockade therapeutics. In this post-doctoral role, you will focus on characterizing the immune infiltrate in tumor models and clinical samples using cutting edge single cell sequencing techniques. By providing better understanding of the range of myeloid cell types in the TME and differentiating the effects of AstraZeneca’s myeloid targeting-drugs on the immune response, you will provide insights into how to best use these drugs in the clinical setting. /p p Your primary objectives will be to develop expertise in generating and interpreting single cell transcriptomic data; to characterize the breadth of myeloid/lymphoid cell subtypes in the TME +/- different drug treatments of mouse tumor models; and to extend this knowledge to clinical samples. /p p You’ll have the opportunity to work with leading academic labs to develop expertise in single cell sequencing approaches and also generate clinically relevant data. As a member of a highly motivated and experienced multidisciplinary Oncology team you’ll share our focus on publishing cutting edge research and bringing new medicines to cancer patients. /p