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Scientist I - AAV 9/16/2017

MedImmune, LLC Gaithersburg, MD

Gaithersburg, MD
AJE Ref #
Job Classification
Full Time
Job Type
Company Ref #
Mid-Career (2 - 15 years)
Doctoral Degree


div div b Location: /b div span Gaithersburg, /span span Maryland, /span span United States /span /div /div span b Job reference: /b R-011520 /span br span b Posted date: /b Sep. 12, 2017 /span br ul style="margin-top:40px;" /ul /div div p u b Main duties and responsibilities /b /u /p p The main duties for the ideal candidate are to help build the internal AAV platform capable of using viral approaches to support MedImmune’s pipeline projects. This candidate will be responsible for developing the next generation of AAV technology for targeted delivery with improved efficacy, potency, transduction, safety and manufacturability. In addition, you will be working in a multidisciplinary matrix environment to drive programs forward and conceive, design, and execute the technique strategies aiming to generate novel AAV variants for desired properties. You will also plan and hands-on execution of experiments on the bench. /p p u b Essential Requirements /b /u /p ul li Ph.D. in AAV Biology, Virology, Cell Biology or relevant scientific discipline with 3+ years of post-doctoral relevant experience /li li Extensive experience and in-depth knowledge with AAV research and gene therapy as evidenced by strong publications. /li li Prior experience in optimizing AAV vector structural components for targeted viral deliveries and/or evading the preexisting neutralizing antibodies. /li li Proven ability to work independently and effectively plan and organize work activities and prioritize task completion to meet schedules and deadlines /li li Experience in mammalian cell culture, molecular biology, protein biochemistry, immunoassays, flow cytometry, and quantitative PCR methods /li li Must be able to multi-task, manage multiple projects simultaneously /li li Strong motivation, attention to detail, ability to think independently and fully integrate into a high achieving team environment /li /ul p u b Desirable requirements /b /u /p ul li Experience with AAV capsid library construction and screening for improved properties /li li Experience with adenovirus, herpes simplex virus, and baculovirus /li li Experience in gene correction and genome editing using CRISPR /li li Strong collaboration and team-working skills /li li Excellent verbal communication, interpersonal and organizational skills /li /ul /div