Scientist - In-Vivo Immunopharmacology
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POST DATE 10/12/2017
END DATE 7/26/2018
JOB DESCRIPTIONA career with EMD Serono is an ongoing journey of discovery: our 50,000 people are shaping how the world lives, works and plays through next generation advancements in healthcare, life science and performance materials. For 350 years and across the world we have passionately pursued our curiosity to find novel and vibrant ways of enhancing the lives of others. EMD Serono is a business of Merck KGaA, Darmstadt, Germany.
The immuno-oncology department at EMD Serono seeks to develop novel therapeutical approaches which aim to modulate the anti-tumor immune response to gain clinically meaningful benefit for patients. The group focuses on both biological and small molecule approaches to achieve this goal.
The successful candidate will be responsible for the hands-on execution of in vivo immunopharmacology studies that utilize mouse tumor models to study the anti-tumor activity of novel immuno-oncology agents. The successful individual will contribute to the execution of a research strategy focused on the evaluation of novel combination approaches for cancer immunotherapy. Through applied expertise in tumor immunology, the incumbent will be charged with characterizing the immunological mechanisms associated with treatment and the identification of potential biomarkers.
Who you are:
We are looking for an experienced in vivo immunopharmacology scientist to drive early drug discovery projects in Immuno-Oncology by designing and conducting in vivo pharmacology studies in murine tumor models
* Bachelor's degree with 3+ years of experience, or MS degree, fluency in written and spoken English is required.
* 3+ years of industry experience preferred
* Keep abreast of cutting-edge in vivo models that can be applied to concept discovery and drug candidate characterization
* The candidate should be proficient in handling rodents (rats, and mice), able to prepare formulations, administer compounds via various routes (IV, PO, IP), and collect blood as well as various tissue samples for analysis, and in vivo fluorescence imaging.
* Apply PK/PD relationship concepts to optimize the dose & schedule for novel biological and small molecule agents
* Focus on immune readouts (i.e., experience in multi-color FACS-based assays, T cell activation assays, ELISA) that can be incorporated into an early clinical development setting
* The candidate should be proficient in data collection/documentation all study results in the form of lab notebook reports and, as needed, contribute to the authorship of regulatory submission documents
* Follow and promote safety instructions and regulations according to Quality Management Standards.
What we offer: With us, there are always opportunities to break new ground. We empower you to fulfil your ambitions, and our diverse businesses offer various career moves to seek new horizons. We trust you with responsibility early on and support you to draw your own career map that is responsive to your aspirations and priorities in life. Join us and bring your curiosity to life!
Curious? Apply and find more information at come2emd.com
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