img src="https://counter.adcourier.com/Sm9zZXBoLlJ1c3NvLjgyNzI3LjQyNDNAcGZpemVyLmFwbGl0cmFrLmNvbQ.gif" p strong ROLE SUMMARY /strong br / br / Recent advances in functional genomics technologies have led to unprecedented opportunities to deepen our understanding of disease biology, screen for new drug targets, and validate candidate targets arising from genetic association and other studies. As integral part of Pfizer Worldwide Research and Development our Functional Genomics group works to establish and apply experimental tools including screens for examining gene function, in order to bring the best targets into the Oncology Research Unit's portfolio and deepen our knowledge of targets under development. br / br / We are seeking a highly motivated and pro-active cancer biologist or immunologist, with expertise in flow cytometry and gene modulation technologies (shRNA/CRISPR), to contribute to the success of the Functional Genomics laboratory in Pearl River, NY. This is an exciting opportunity to apply cutting-edge methods and contribute with our team to the target portfolio of one of the world's leading developers of novel therapeutics. br / br / strong ROLE RESPONSIBILITIES /strong * Careful planning, independent execution, trouble-shooting, as well as data analysis support of day- to multi-week-long experiments to test the functional consequences of genetic variants and pharmacologic agents in cell-based model systems, using co-culture systems and cell engineering methods that include lenti-/retroviral transduction and CRISPR-based gene editing technologies. br / * Perform cutting-edge genomic and phenotypic CRISPR-based screens to identify new targets in immuno-oncology using advanced murine and human cell culture and transplantation systems. br / * Assist with the evaluation of new approaches and pro-actively introduce improvements to the offerings of the Functional Genomics group. br / * Work and communicate closely with other Pearl River colleagues and support interaction with our Oncology Research Unit partner sites in San Diego (La Jolla) and the Bay Area (South San Francisco). br / * Present research results and discuss methods at weekly/monthly group meetings.